doi: 10.1016/j.yebeh.2019.03.018 171
Br J Pharmacol 126: 296300
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In IDD cells, m decreases while MitoROS levels increase, indicating mitochondrial dysfunction (57,58)
Pellerin and Magistretti originally proposed the astrocyte-neuron lactate shuttle (ANLS) model, wherein lactate released from astrocytes serves as a buffer compound in response to a glutamate-induced glycolysis stimulus [25]
However, it is unclear to what extent the in vitro observations correspond to metabolic and disease processes seen in vivo 12
